International Review of Ophthalmology ›› 2022, Vol. 46 ›› Issue (5): 424-429.doi: 10.3760/ cma.j.issn.1673-5803.2022.05.008

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Application of nanotechnology on diagnosis and treatment of diabetic retinopathy

Wang Feng1, Shao Yi2   

  1. 1Department of Ophthalmology, Meizhou Pepole's Hospital, Meizhou 514000, China; 2 Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China
  • Received:2021-08-29 Online:2022-10-22 Published:2022-11-04
  • Contact: Shao Yi, Email: freebee99 @ 163.com E-mail:freebee99 @ 163.com
  • Supported by:
    National Natural Science Foundation of China(82160195); Central Government Guides Local Science and Technology Development Foundation (20211ZDG02003); Key Research Foundation of Jiangxi Province (20181BBG70004, 20203BBG73059); Research and Cultivation Project of Guangdong Meizhou People's Hospital (PY-C2021060)

Abstract: Nanotechnology can use the special properties of nanoparticles to modify the surface of nanoparticles, which was used to produce sodium fluorescein modified with polyvinyl imine nanoparticles (PEI-NHAc-FS NP), can not only retain the optical properties of sodium fluorescein for the diagnosis of retinal and choroidal diseases, but also have a faster metabolic rate than free sodium fluorescein, so as to safely and effectively diagnose diabetes retinopathy (DR). The progress of DR can be monitored by detecting the metabolic characteristics of plasma by vanadium core-shell nanorods assisted laser desorption/ionization mass spectrometry. Encapsulated drugs in nanoparticles can form drug delivery carriers with targeted, controlled release and easy detection, which provides a new idea for the treatment of DR.(Int Rev Ophthalmol, 2022, 46: 424-429)

Key words: diabetic retinopathy, nanotechnology